Development of new chemical oxidative, step and atom efficient C-N and N-N bond forming coupling reactions

Vemuri, Pooja Yasaswi; Patureau, Frédéric (Thesis advisor); Albrecht, Markus (Thesis advisor)

Aachen : RWTH Aachen University (2022)
Dissertation / PhD Thesis

Dissertation, RWTH Aachen University, 2022

Abstract

In this dissertation, ambitious strategies were proposed to construct novel C-N and N-N bonds between organic molecules that are of profound importance in the pharmaceutical, drug discovery and organic material fields, using the concept of cross dehydrogenative coupling. As an alternative to traditional cross coupling methods, strategies that produce minimal by products are designed in an atom efficient manner. More specifically, chemical oxidants are utilised as pivotal reagents in the construction of novel C-N and N-N bonds with high regioselectivity. In this way, it is hoped that more CDC strategies will be developed in future to expand the concept of C-H or N-H bond functionalisation. Furthermore, the aim is to gain more fundamental insights into how to achieve heterocoupling between substrates, rather than the homocoupling background reaction which is commonly observed in oxidative cross coupling strategies. The works described in this dissertation suggest possible methods to surpass this challenge, which will potentially enable many future CDC strategies in diverse classes of organic molecules.

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