N-Funktionalisierungen an Sulfoximinen : N-Alkinylierte, N-Tetrafluorpyridylierte und N-Schwefel-funktionalisierte Sulfoximine

  • N-Functionalization of sulfoximines : N-alkynylated, N-tetrafluoropyridylated, and N-sulfur-functionalized sulfoximines

Fergen, Hannah; Bolm, Carsten (Thesis advisor); Albrecht, Markus (Thesis advisor)

Aachen : RWTH Aachen University (2022)
Dissertation / PhD Thesis

Dissertation, RWTH Aachen University, 2022


Sulfur-containing functional groups are of great significance in the search for bioactive scaffolds, and among these, sulfoximines are attracting increasing attention. This work deals with the N-functionalizations of sulfoximines. In the first part, N-alkynylated sulfoximines are studied, investigating the synthesis of terminal N-alkynyl groups and the reactivity with azomethine ylides. The second part of the work describes the base-mediated production of N-tetrafluoropyridylated sulfoximines. In the third part, the focus is on N-sulfur functionalized sulfoximines. The regioselective synthesis and reactivity of sulfoximidyl-dithiocarbamates are studied. Furthermore, the preparation of sulfoximidyl-sulfamates via N-chlorosulfonyl and N-sulfonato-sulfoximines is described.